MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4
نویسندگان
چکیده
منابع مشابه
MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4.
The role of microRNA-1 (miR-1) has been studied in cardiac and skeletal muscle differentiation. However, it remains unexplored in vascular smooth muscle cells (SMCs) differentiation. The aim of this study was to uncover novel targets of and shed light on the function of miR-1 in the context of embryonic stem cell (ESC) differentiation of SMCs in vitro. miR-1 expression is steadily increased dur...
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Kruppel-like factor 4 (Klf4) is a transcription factor that regulates many important cellular processes in stem cell biology, cancer, and development. We used histological and molecular methods to study the expression of Klf4 in embryonic development of the normal and Klf4 knockout cerebellum. We find that Klf4 is expressed strongly in early granule cell progenitor development but tails-off con...
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ژورنال
عنوان ژورنال: Stem Cells and Development
سال: 2011
ISSN: 1547-3287,1557-8534
DOI: 10.1089/scd.2010.0283